The use of α -Arbutin in cosmetics is safe for consumers, with concentrations up to 2% in face creams and 0.5% in moisturizers.Ģ. SCCS has previously assessed the safety of both α -Arbutin and β -Arbutin in SCCS/1552/15 and SCCS/1550/15, respectively. 5, has been banned in the EU since 26 July 2021. ![]() Deoxyarbutin, or Tetrahydropyranoxyphenol, Deoxyarbutin, CAS No. β-Arbutin is cheap and widely used in cosmetics α -Arbutin and Deoxyarbutin are new whitening ingredients, which are better than β -arbutin in whitening effect, but less used than β -arbutin. CAS Number of Alpha-Arbutin is 84380-018. Therefore, its security receives the media and the consumer's attention.īased on differences in chemical structure, Arbutin can be divided into α -arbutin, β -arbutin and Deoxyarbutin. However, Arbutin may be converted to Hydroquinone under conditions such as low pH, high temperature, UV irradiation and other conditions, or under the action of human skin microorganisms or glucosidase, resulting in potential risks of sensitization, genotoxicity or carcinogenesis. At the same time, it also has the function of desalinating melanin that has been formed and reducing the deposition of skin pigment. ![]() The draft opinion is open for public comment until May 27, 2022.Īrbutin can inhibit tyrosinase activity effectively by directly binding itself to tyrosinase, competing for the binding site of Dopa, blocking the synthesis of Dopa and Dopa Quinine, and thus interfering with melanocytes and inhibit the production of melanin. On 25 March 2022, the European Scientific Committee for Consumer Safety (SCCS) issued draft opinion on the safety of Alpha-Arbutin and Beta-Arbutin, in which it concludes that without data on Hydroquinone release and its ultimate destination, it is not possible to determine the safe concentration of any Arbutin in cosmetics.
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